Description

Selank – Advanced Biochemical Mechanism Profile

(Synthetic Tuftsin Analog; Heptapeptide; Neuromodulatory Research Peptide)

Selank is a stabilized analog of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). In research models, Selank influences GABAergic and monoaminergic neurotransmission and modulates transcription of neurotrophic and immune-related genes.

✅ 1. Primary Molecular Interactions (In-Vitro Models)

A. GABAA_AA​ Receptor Allosteric Modulation

• Binds allosteric sites on GABAA_AA​ receptors

• Enhances GABA binding affinity

• Increases Cl⁻ influx

• Produces inhibitory postsynaptic stabilization in neuronal cultures

Biochemical outcome:

• ↑ GABAergic tone

• ↓ Neuronal excitability

• ↓ Ca²⁺ influx via voltage-gated Ca²⁺ channels

B. Monoamine Regulation

Selank has been shown to influence turnover and release of:

• Serotonin

• Dopamine

• Norepinephrine

Likely via presynaptic modulation and feedback on monoamine transporters and synthesis enzymes (e.g., TPH2, MAOA, COMT) in research systems.

C. Enkephalin Metabolism

Selank may inhibit enkephalin-degrading peptidases (e.g., enkephalinase), increasing endogenous opioid peptide levels in vitro.
Effects observed:

• ↑ enkephalin availability

• ↑ opioid receptor signaling

• Reduced excitatory neurotransmission

✅ 2. Intracellular Signaling Pathways

A. GABAA_AA​ → Cl⁻ Currents

• Hyperpolarization of neuronal membrane

• Decreased Ca²⁺-dependent neurotransmitter release

B. Anti-inflammatory Cytokine Modulation

Cell-culture studies show altered expression of:

• ↓ IL-6, TNF-α

• ↑ IL-10
  Likely mediated by NF-κB pathway inhibition and cytokine-gene promoter regulation.

C. BDNF & Neurotrophic Signaling

Selank increases transcription of:

• BDNF

• GDNF

• NGF-receptor–associated genes

Downstream pathways include:

• CREB phosphorylation

• ERK1/2 and Akt signaling in neuronal viability models

✅ 3. Second Messengers

✅ 4. Gene Targets Commonly Measured in Research

✅ Mechanistic Summary

• Allosteric modulation of GABAA_AA​ receptors

• Influences monoamine turnover and transporter function

• Modulates ERK/CREB signaling and neurotrophic gene transcription

• Regulates NF-κB–linked cytokine genes in immune-neural crosstalk

• Promotes synaptic stability and reduced excitatory drive in neuronal cultures

Research-Only Classification

Selank is supplied exclusively for in-vitro laboratory research.
Not approved for human or animal administration, therapeutic use, or biological application outside controlled research environments.