Description

GLOW Blend – Advanced Biochemical Mechanism Profile

GHK-Cu (45 mg) / BPC-157 (10 mg) / TB-500 (10 mg)
Copper peptide + cytoprotective peptide + actin-binding peptide

This blend combines three research peptides frequently examined for their complementary roles in extracellular matrix (ECM) signaling, cytoskeletal dynamics, and transcriptional regulation.

✅ 1. GHK-Cu

Tripeptide copper-transport complex

Primary Biochemical Actions

• High affinity binding of Cu²⁺, supporting copper delivery to enzymatic systems

• Interacts with integrins, heparan sulfate proteoglycans, and ECM proteins

Enzyme & Pathway Targets

• Lysyl oxidase (LOX) → crosslinking of collagen/elastin

• Cu/Zn-SOD → antioxidant enzyme regulation

• MMP/TIMP signaling → matrix remodeling

• TGF-β/SMAD2/3 → ECM gene transcription

Genes frequently monitored

• COL1A1, COL3A1, ELN, FN1 (matrix production)

• TIMP1/2, MMP-2/9 (protease regulation)

• SOD1, GPX1, HMOX1 (antioxidant response)

• Anti-inflammatory transcription ↓ NF-κB–dependent cytokines

✅ 2. BPC-157

Pentadecapeptide studied in angiogenesis, tight-junction stability, and cytoskeletal regulation

Receptor/Pathway Profiles

BPC-157 does not rely on a single classical receptor; research indicates indirect modulation of:

• eNOS → NO/cGMP signaling

• VEGFR2 → angiogenic signaling

• FAK/SRC phosphorylation → cell migration & cytoskeletal remodeling

• MAPK (ERK1/2, p38, JNK)

• NF-κB suppression in inflammatory models

Gene & Protein Targets

• VEGFA, KDR (VEGFR2) → endothelial proliferation/migration

• ZO-1, Claudin, Occludin → tight-junction proteins

• IL-1β, TNF-α, COX-2 → inflammatory gene modulation

• β-catenin & integrin-linked genes → cytoskeleton organization

✅ 3. TB-500 (Thymosin Beta-4 fragment)

Actin-binding G-actin sequestering peptide

Primary Mechanisms

• Binds G-actin → increases G-actin pool availability

• Regulates F-actin polymerization, lamellipodia and filopodia formation

• Supports cell migration and ECM remodeling models

Signaling & Enzyme Targets

• FAK and integrin-linked kinase (ILK) pathways

• Matrix metalloproteinases (MMP-2, MMP-9)

• TGF-β1/SMAD signaling

• Modulation of eNOS/NO signaling in endothelial studies

Gene Targets

• ACTB / ACTG1 (actin cytoskeletal genes)

• COL1A1 / FN1 (matrix genes)

• MMP-2/MMP-9 and TIMP1

• Anti-inflammatory transcriptional suppression via NF-κB

✅ Synergistic Mechanistic Areas

Because all three peptides converge on ECM and cytoskeletal pathways, research commonly evaluates:

✅ Key Molecular Targets (Condensed)

• Enzymes: LOX, Cu/Zn-SOD, MMP-2/9, eNOS, FAK, SRC

• Second Messengers: NO/cGMP, ERK1/2, p38, JNK, SMAD2/3

• Genes: COL1A1, COL3A1, ELN, FN1, VEGFA, TIMP1/2, ZO-1, SOD1, GPX1

Research-Only Classification

This blend is provided strictly for controlled in-vitro laboratory research.
Not for human or animal use, ingestion, injection, or therapeutic application.