This material is suppliedΒ exclusively as a laboratory research chemicalΒ forΒ in vitro scientific study. All descriptions and documentation are providedΒ for informational and educational purposes only.
This compound isΒ not approvedΒ for human or animal consumption, injection, ingestion, inhalation, topical use, or any other biological application. It must be handled only by qualified, trained personnel in a properly equipped laboratory.
This product isΒ notΒ a drug, supplement, food, cosmetic, or therapeutic agent, and it may not be rebranded, repackaged, or marketed as any such item.Β Misuse, mislabeling, or unauthorized application is strictly prohibited.
Nothing on this website constitutes medical advice, professional guidance, or a recommendation of use.
(Epithalamin-Derived Tetrapeptide; Telomerase & Circadian Gene Modulation Peptide β Research Use Only)
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled after the active component of the pineal peptide extract Epithalamin.
In vitro and molecular biology research indicates that Epithalon influences telomeric DNA maintenance, circadian gene transcription, and oxidative defense pathways via telomerase activation, shelterin protein regulation, and SIRT/FOXO transcriptional signaling.
Although Epithalon does not bind a classical cell surface receptor, observed activity involves:
| Target System | Role |
|---|---|
| TERT (telomerase reverse transcriptase) | Telomere elongation & chromosomal end protection |
| Shelterin Complex Proteins | TRF1, TRF2, POT1, TPP1 telomere stabilization |
| SIRT1 / SIRT3 | Epigenetic and mitochondrial regulation |
| CLOCK/BMAL1 | Circadian transcriptional machinery |
Epithalon has been shown to upregulate:
TERT gene transcription
Assembly of telomerase holoenzyme (TERT + TERC)
Telomeric DNA repeat synthesis (TTAGGG)n
Research reports increased expression of:
TRF1 / TRF2 β telomere-capping proteins
POT1, TPP1 β single-stranded telomeric DNA protection
These proteins prevent DNA damage signaling at chromosome ends.
Epithalon modulates central clock genes and transcription loops:
β CLOCK / BMAL1 expression
Normalization of PER1 / PER2 feedback cycles
Crosstalk with melatonin regulatory pathways in pinealocyte models
Circadian normalization affects downstream metabolic gene oscillation.
| Enzyme / Factor | Mechanistic Role |
|---|---|
| Telomerase (TERT + TERC) | Telomere extension |
| SIRT1 | NADβΊ-dependent deacetylation of p53, FOXO, and clock proteins |
| FOXO1 / FOXO3a | Stress-response transcription factors |
| p53 / p21 | Cell cycle and DNA-damage checkpoints |
| Catalase, SOD2, GPX1 | Antioxidant enzyme induction |
Second messengers:
NADβΊ/SIRT axis
CaΒ²βΊ-dependent nuclear signaling
AMPK and MAPK phosphorylation patterns in some cell lines
| Functional Category | Gene Examples |
|---|---|
| Telomere Maintenance | TERT, TRF1, TRF2, POT1, TPP1 |
| Circadian Regulation | CLOCK, BMAL1, PER1, PER2, CRY1 |
| Antioxidant Defense | SOD2, CAT, GPX1, HMOX1 |
| Cell Cycle | p53, p21 (CDKN1A), GADD45A |
| Mitochondrial Function | NRF1, TFAM |
Epithalon has shown transcriptional and enzymatic responses including:
β antioxidant enzyme gene expression (SOD2, CAT)
β oxidative stress markers via NF-ΞΊB suppression
Mitochondrial biogenesis via PGC-1Ξ± / NRF1 / TFAM axis
Synthetic tetrapeptide analog of epithalamin
Modulates telomerase, shelterin proteins, and circadian transcription loops
Interacts with SIRT1/FOXO stress-response pathways
Alters transcription of DNA-maintenance, antioxidant, and mitochondrial genes in vitro
Epithalon is a research peptide, not a supplement, drug, or therapeutic agent.
It is supplied only for in-vitro laboratory experimentation, not for human or animal use, ingestion, injection, or biological application.
| Weight | N/A |
|---|---|
| Size | 10 Mg, 50 Mg |
