This material is suppliedΒ exclusively as a laboratory research chemicalΒ forΒ in vitro scientific study. All descriptions and documentation are providedΒ for informational and educational purposes only.
This compound isΒ not approvedΒ for human or animal consumption, injection, ingestion, inhalation, topical use, or any other biological application. It must be handled only by qualified, trained personnel in a properly equipped laboratory.
This product isΒ notΒ a drug, supplement, food, cosmetic, or therapeutic agent, and it may not be rebranded, repackaged, or marketed as any such item.Β Misuse, mislabeling, or unauthorized application is strictly prohibited.
Nothing on this website constitutes medical advice, professional guidance, or a recommendation of use.
Fragment 177-191 of Human Growth Hormone (hGH)
AOD-9604 is a synthetic peptide corresponding to the C-terminal 15βamino-acid region (177-191) of human growth hormone. In research models, this fragment retains a subset of hGHβs metabolic signaling properties without activating the classical growth hormone receptor (GHR), making it useful for studying metabolic pathways independent of IGF-1βmediated growth signaling.
Unlike full-length hGH, AOD-9604 does not induce IGF-1 production via JAK2/STAT5 activation.
Instead, in in-vitro research, AOD-9604 is investigated for:
Enhanced lipolytic enzyme activity
Fatty-acid mobilization
AMP-activated protein kinase (AMPK) signaling
cAMP-dependent pathways
Research indicates AOD-9604 can modulate HSL (hormone-sensitive lipase) and ATGL (adipose triglyceride lipase)βtwo core enzymes regulating triglyceride breakdown.
| Target | Research Activity |
|---|---|
| HSL (Hormone-Sensitive Lipase) | Triglyceride β diglyceride conversion |
| ATGL | Initial hydrolysis of stored triglycerides |
| CPT-1 | Fatty-acid transport into mitochondria |
| ACC (Acetyl-CoA Carboxylase) | Inactivated when AMPK is active β increased Ξ²-oxidation |
| AMPK | Energy-sensing enzyme that shifts metabolism toward fat oxidation |
Research models demonstrate increased phosphorylation of AMPK and decreased activity of ACC, promoting mitochondrial fatty-acid entry and Ξ²-oxidation.
In adipocyte and metabolic studies, AOD-9604 has been associated with:
β cAMP accumulation
PKA activation
AMPK phosphorylation
Increased mitochondrial fatty-acid oxidation
These pathways bypass full hGH receptor activation, offering a tool to study selective metabolic signaling without inducing growth-related JAK/STAT pathways.
Research interest has focused on changes in transcription factors and metabolic genes such as:
PGC-1Ξ± β mitochondrial biogenesis regulator
CPT1A / CPT1B β fatty-acid transport genes
ACOX1, ACADs β peroxisomal and mitochondrial Ξ²-oxidation
PPAR-Ξ± and PPAR-Ξ΄ β lipid-metabolism nuclear receptors
UCPs (uncoupling proteins) β thermogenic and oxidative capacity genes
These are investigated for their role in shifting metabolism toward fatty-acid utilization.
| Property | hGH | AOD-9604 |
|---|---|---|
| Binds Growth Hormone Receptor | β Yes | β Not observed |
| Activates JAK2/STAT5 β IGF-1 | β Yes | β Not observed |
| Metabolic / Lipolytic Signaling | β Yes | β Yes |
| Research Focus | Growth & metabolism | Selective metabolism only |
This distinction makes AOD-9604 valuable for non-IGF-1-mediated metabolic studies.
AOD-9604 is supplied strictly for in-vitro laboratory and scientific research.
It is not a drug, supplement, therapy, or diagnostic agent, and is not approved for human or animal use.
| Weight | N/A |
|---|---|
| Size | 5 Mg |
