BPC-157 5mg

Description

BPC-157 – Advanced Biochemical Mechanism & Pathway Profile

Body Protection Compound-157 (Pentadecapeptide)

BPC-157 is a 15-amino-acid synthetic peptide derived from a partial sequence of a naturally occurring gastric protein. In laboratory research, it is studied for interactions with angiogenic signaling, cytoskeletal regulation, and cell-junction stability. Unlike growth-factor peptides, BPC-157 does not require classical growth-factor receptors; instead, models suggest indirect modulation of multiple intracellular cascades.

✅ Primary Signaling Systems Studied

Research models have associated BPC-157 with the following biochemical pathways:

1. Nitric Oxide (NO) / eNOS Pathway

• BPC-157 has been linked to modulation of endothelial nitric oxide synthase (eNOS)

• Suggested influence on NO availability, vasodilation signaling, and cytoskeletal dynamics

Enzymes and downstream targets frequently evaluated:

• eNOS phosphorylation

• PI3K/Akt → eNOS activation pathway

• cGMP signaling

2. Growth-Associated Signaling (VEGF and FAK)

Though not a direct VEGF agonist, studies examine possible upregulation of:

• VEGF (Vascular Endothelial Growth Factor)

• VEGFR2

• FAK (Focal Adhesion Kinase)

These targets relate to endothelial migration, angiogenesis models, and cytoskeletal remodeling.

Gene targets studied:

• VEGFA

• KDR (VEGFR2)

• ITGB3 / ITGA5 (integrin signaling)

• Paxillin & focal adhesion proteins

3. Cytoskeletal & Cell-Junction Pathways

Laboratory work shows interest in interactions with:

• Actin & myosin filament reorganization

• ZO-1 (Tight-junction protein 1)

• Occludin / Claudin family proteins

These proteins regulate epithelial and endothelial barrier integrity.

✅ MAPK / ERK & JAK/STAT Cascades

Some models report altered activity in:

• ERK1/2 phosphorylation

• p38 MAPK

• JNK pathways

• STAT3 nuclear signaling

These pathways are central to gene transcription and cellular repair mechanisms.

✅ Inflammatory & Immune-Related Targets

Research also explores modulation of inflammatory mediators at the biochemical level:

• NF-κB pathway suppression models

• Cytokine gene transcription (TNF-α, IL-1β, IL-6)

• COX-2 and iNOS expression changes

These findings remain specific to controlled preclinical experiments.

✅ NO-Independent Angiogenic & Cellular Effects

Some studies describe BPC-157 influencing:

• SRC & FAK phosphorylation

• β-catenin signaling

• E-cadherin and tight-junction gene maintenance

This connects peptide exposure to cytoskeleton regulation and intercellular junction stability.

Key Molecular Targets Studied

Research Applications (In-Vitro / Preclinical Only)

BPC-157 is used in controlled models to study:

• Angiogenic signaling & endothelial migration

• Nitric-oxide–related cellular pathways

• Tight-junction protein stability

• Cytoskeletal remodeling

• Transcriptional shifts in inflammatory mediators

• Growth-factor signaling crosstalk

Research-Only Classification

This compound is supplied exclusively for in-vitro laboratory research.
It is not a drug, supplement, treatment, or diagnostic agent and is not approved for human or animal use.